Uses
ChemicalBook > CAS DataBase List > Infigratinib

Infigratinib

Uses
Product Name
Infigratinib
CAS No.
872511-34-7
Chemical Name
Infigratinib
Synonyms
BGJ-398;Infligratinib;BGJ;CS-218;BGJ 398;NVP-BGJ398;Infigratinib;Transcrocetinate;NVP-BGJ398, >=98%;BGJ398 (NVP-BGJ398)
CBNumber
CB52589643
Molecular Formula
C26H31Cl2N7O3
Formula Weight
560.48
MOL File
872511-34-7.mol
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Infigratinib Property

Melting point:
>211°C (dec.)
Boiling point:
747.9±60.0 °C(Predicted)
Density 
1.354
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 5 mg/ml)
form 
White solid.
pka
11.02±0.70(Predicted)
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19157
Product name
BGJ398
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
19157
Product name
BGJ398
Purity
≥98%
Packaging
5mg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
19157
Product name
BGJ398
Purity
≥98%
Packaging
10mg
Price
$191
Updated
2024/03/01
Cayman Chemical
Product number
19157
Product name
BGJ398
Purity
≥98%
Packaging
25mg
Price
$313
Updated
2024/03/01
TRC
Product number
B367000
Product name
BGJ398
Packaging
200mg
Price
$425
Updated
2021/12/16
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Infigratinib Chemical Properties,Usage,Production

Uses

BGJ 398 is a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.

Description

NVP-BGJ398 (872511-34-7) is a potent and selective pan-FGFR inhibitor (IC50?= 0.9nM, 1.4 nM, 1.0 nM, and 60 nM for FGFR1,2,3,4 respectively).1? It has also been used in a mouse model of Achondroplasia (most common form of dwarfism) to correct pathological hallmarks of this condition.

Uses

BGJ 398 is a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.

Definition

ChEBI: BGJ-398 is a member of the class of phenylureas that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 2,6-dichloro-3,5-dimethoxyphenyl group, while the hydrogens attached to the other nitrogen are replaced by a methyl group and a 6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl group. It is a potent and selective fibroblast growth factor receptor inhibitor. It has a role as a fibroblast growth factor receptor antagonist and an antineoplastic agent. It is an aminopyrimidine, a N-arylpiperazine, a N-alkylpiperazine, a dichlorobenzene and a member of phenylureas.

target

FGFR1

References

1) Guagnano?et al.?(2011),?Discovery of 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)-1-methylurea (NVP-BGJ398),?a Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase?; J. Med. Chem.?54?7066 2) Komla-Ebri?et al.?(2016),?Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model; J. Clin. Invest.?126?1871

Infigratinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Infigratinib Suppliers

AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2784
Advantage
58
ApexBio Technology LLC
Tel
+1-832-696-8203
Fax
+1-832-641-3177
Email
info@apexbt.com
Country
United States
ProdList
477
Advantage
60
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4662
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63711
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
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View Lastest Price from Infigratinib manufacturers

shandong perfect biotechnology co.ltd
Product
Infigratinib (BGJ398) 872511-34-7
Price
US $0.00/g
Min. Order
1g
Purity
98% HPLC
Supply Ability
1kg
Release date
2023-08-02
Career Henan Chemical Co
Product
3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea 872511-34-7
Price
US $2.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
ask
Release date
2020-01-08

872511-34-7, InfigratinibRelated Search:


  • 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea
  • BGJ 398
  • BGJ-398
  • BGJ398 (NVP-BGJ398)
  • NVP-BGJ398
  • 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea NVP-BGJ398
  • NVP-BGJ398 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea
  • Urea, N'-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl-, methanesulfonate
  • Urea, N'-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl-
  • NVP-BGJ398, >=98%
  • NVP-BGJ398 (Infigratinib)
  • CS-218
  • NVP-BGJ398; BGJ398; BGJ-398;INFIGRATINIB;BGJ 398
  • BGJ
  • BGJ-398 phosphate,NVP-BGJ398 phosphate,Infigratinib phosphate
  • Transcrocetinate
  • BGJ398 (NVP-BGJ398);BGJ-398; BGJ 398; NVP BGJ398
  • 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-
  • NVP-BGJ398(BGJ-398,Infigratinib)
  • Infligratinib
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  • Infigratinib
  • 872511-34-7
  • 72511-34-7
  • C26H31Cl2N7O3
  • Inhibitors
  • Inhibitor
  • API